Support for this activity provided by TDO
2017 PERF Scientific Session
I will be presenting two lectures which relate two puzzling concepts in biology: The reality of disorder and randomness in biology, and how order and organization can arise from such disorder. Understanding these fundamental principles is essential to gain a clear understanding of bacterial biology and associated diseases.
The first lecture focuses on very basic yet far reaching questions with direct medical impact. Some of the questions we will explore are: Why do certain diseases appear to unexpectedly “pop” into existence? Why do not all cells respond in the same way to a given drug? Surprisingly, the answer to these questions turns out to be based on “chance events”, or more technically speaking stochasticity. In my lecture, I will discuss recent landmark findings that uncovered stochastic processes in biology. We will explore examples that show how chance events are in fact deeply rooted in the molecular interactions that underlie all biological processes. We will discuss examples ranging from development to microbial resistance to antibiotics. At the end of this lecture we will understand how and why cells sometimes “gamble” or “flip a coin” to make a decision.
In the second lecture we will discuss the poorly understood world of bacteria that reside in the context of biofilm communities. We will see that bacteria in biofilms can gain functions and behaviors that are only possible in the context of the collective, and have thus eluded scientists and even resulted in misunderstanding of antibiotic resilience. Among others, I will address the long-standing question regarding the native functional role of bacterial potassium ion channels, by showing that they serve an unexpected cell-to-cell signaling function in biofilms. Bacteria can thus achieve complex behaviors that are only possible through collective coordination of membrane potential. Therefore, numerous biomedically relevant bacterial processes that directly depend on the membrane potential, are likely to be governed by electrical signaling in biofilms, suggesting new research directions that could not have been envisioned prior to this discovery.
What attendees can expect to learn:
- The concept of randomness in biology from a molecular perspective
- Functional and therapeutic consequences of randomness in biology
- E pluribus unum: Order from disorder in bacterial communities
- How bacterial communities achieve unexpected properties through electrical signaling
- New frontiers in biofilm biology
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This continuing education activity has been planned and implemented in accordance with the standards of the ADA Continuing Education Recognition Program (ADA CERP) through joint efforts between CLINICAL RESEARCH FOUNDATION and PACIFIC ENDODONTIC RESEARCH FOUNDATION.
Clinical Research Foundation212 Church Ave. Chula Vista, CA 91910
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Ph: 858.558.3636 / Fax: 858.558.3633