Support for this activity provided by TDO
Mitochondrial Disease & Chronic Fatgue Syndrome Autism
Methods in systems biology now permit scientists to measure hundreds of molecular and physiologic abnormalities in any chronic illness. Experience has shown that treatments directed at any one abnormality is rarely curative and usually results in having to take a medicine for life, even though it only produces marginal benefits and never cures. For example, insulin can be taken for diabetes, but no one is cured of their diabetes with insulin. A statin can be taken for high cholesterol, but dyslipidemia is not cured by statins. The cell danger response (CDR) is a universal response to injury. Three metabolic stages of the CDR comprise the healing cycle. Fundamental discoveries in our lab have shown that mitochondria are the central regulators of the CDR and healing. This is accomplished via metabolites called metabokines that serve two functions. Inside the cell, they act as everyday metabolites like ATP. Outside the cell, they act as signaling molecules that bind to cellular receptors, change gene expression, and help to manage infections, injuries, and toxin exposures. In this talk, I will show how knowledge of metabolic signaling pathways such as purinergic signaling, can be used to develop new treatments for disorders like autism, for which no FDA-approved treatment has yet been developed.
What are the three stages of the cell danger response and how are they related to healing after any surgery or injury?
What attendees can expect to learn:
A history of the discovery of the cell danger response and its role in many chronic complex illnesses.
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